"Since ancient Greece people have used grapes, grape leaves, and sap for health purposes. Grape seed extract was developed in the 1970s. Today, grape seed extract is used as a dietary supplement for various conditions, including for venous insufficiency (when veins have problems sending blood from the legs back to the heart), to promote wound healing, and to reduce inflammation. Grape seed extract contains the antioxidant compound oligomeric proanthocyanidin (OPC), which has been studied for a variety of health conditions. OPCs are found in extracts of grape skin and seeds, which are by-products of the wine industry. Grape seed extract is available in capsules and tablets and as a liquid."